| RESEARCH
INTERESTS OF THE FACULTY
Department of Pharmaceutical Sciences
Mikhail D. Antoun, Ph.D.
Study of natural products with special emphasis on the flora of
Puerto Rico as potential source of drug leads; Complementary and
Alternative Medicine; study of selected plants as a source of
anti-cancer and anti-tuberculosis bioactives
Joseph Bloom, Ph.D.
Applications of HPLC/MSC in Drug Analysis; quality control in
industrial pharmacy and method development for drug analysis,
chemical properties of extemporaneous preparations
Jorge Duconge, Ph.D.
Population Pharmacokinetic/Pharmacodynamic Data Analysis and
Modeling; Pharmacometrics of monoclonal antibodies, cytokines
and growth factors; kinetics of drug action in disease-state and
clinical trial simulation
Rafael García Berdecía, M.P.H.
Institutional research; admission requirements as predictors of
academic performance of Pharm.D. students in Puerto Rico.
Yamil Gerena, Ph.D.
Development of new fluorescent cell models to understand the
pathogenesis of diabetes and cardiovascular diseases; T cell
expression of insulin receptor and its role in diabetes
mellitus; Development of transgenic fish models as a tool in
drug discovery and development process.
Evone S. Ghaly, Ph.D.
Design and development of new drug products from formulation up
to production; solid and semisolid dosage forms technology;
pharmaceutical material characterization and performance;
enhancement of dissolution; advanced processing; process
analytical technology (PAT); controlled release and delivery
systems.
Eliud Hernández, Ph.D.
Drug discovery of novel antiproliferative agents; drug design
in cancer and malaria
Arturo Martí, Ph.D.
Drug analysis; forensic and drug abuse toxicology
Ilia Oquendo, Ph.D.
Natural products; educational research; clinical research in
dementia, especially early identification of Alzheimer’s disease
and mild cognitive impairment, preventive measures and early
treatment
Marianela Pérez, Ph.D.
Regulation of the epidermal growth factor receptor genes and its
isoforms in breast cancer cell lines by heregulin, a ligand for
ErbB3 and its effects on cancer cells and possible therapeutical
interventions.
Novel protein substrates of the tumor suppressor Phosphatase and
Tensin homolog (PTEN), their implication in the progression of
cancers that are PTEN-deficient, and their potential use as
targets for cancer therapy.
Cornelis Vlaar, Ph.D.
Drug discovery of novel antiprotiferactive agents; drug design
and discovery in cancer and malaria
Elga E. Vega, Ed.D.
Educational research; women’s health; drug-related congenital
birth defects
Department of Pharmacy Practice
Edna Almodóvar, Pharm.D.
Patient centered care; geriatrics; pain management, practice
models
Nelly Conte, MMS
Patient centered care
Iadelisse Cruz, Pharm.D.
Clinical outcomes research; educational research
Sandra M. Fábregas, Ph.D.
Health communication; applied bioethics in medicine and
pharmacy; history in health sciences
Denise Figueroa, Pharm.D.
Geriatrics; diabetes care and management; patient centered care;
educational research
Astrid García Ortiz, Pharm.D.
Pharmaceutical care and health outcomes; renal disease;
diabetes; pharmacy practice models
Lydia González, Pharm.D.
Educational research in clinical psychiatry and women health;
research aimed at closing the gap between the pharmaceutical
care philosophy and the practice of the profession in Puerto
Rico
Myriam González, M.P.H.
Community based pharmacists as counselors on medication
management for Hispanics elderly
Luz M. Gutiérrez, Pharm.D.
Practice models; institutional research; patient centered care
Lesbia Hernández, Pharm.D., MPH
Humanistic Outcomes Research and Pain Management
José Josué Hernández, Ph.D.
Study of factors associated with suboptimal prescribing among
elderly patients, as well as variations in medication use and
prescribing among elderly patients with cognitive impairment.
Francisco J. Jiménez, Pharm.D.
Pharmaceutical care services in community pharmacies; diabetes
education
Wanda Maldonado, Pharm.D.
Educational research; clinical infectious diseases;
pharmacokinetics; toxicities associated with antiretroviral
therapy in pediatric patients
Wanda Marrero, Pharm.D.
Patient centered care; practice models; respiratory diseases
such as asthma and influenza; public health in pharmacy
Mirza D. Martínez, Pharm.D.
Educational research; pharmacy services
Jorge Miranda Massari, Pharm.D.
Pharmacokinetics of natural substances in Hispanic populations;
phytomedicinals and other dietary supplements for chronic
diseases
Gladys Miró, Ed.D.
Assessment of student learning; professional socialization of
pharmacy students; institutional research and assessment
Elsa Pedro, Pharm.D.
Clinical oncology Phase I and Phase II studies
María Pi, Ed.D.
Institutional assessment and evaluation
Dayna Quiñones, Pharm.D.
Patient safety and quality; patient centered care;
acute/critical care pharmacotherapy
Sacha Rivera, Pharm.D.
Medication adherence in geriatrics; medication management in
rheumatoid arthritis (RA); educational research
Frances M. Rodríguez, Pharm.D.
Patient centered care; patient safety, and quality
Betty Ann Torres, Pharm.D.
Patient centered care; educational research in women health
Miriam Varela, Pharm. D.
Secondary prevention of hypertension and osteoporosis;
extemporaneous preparation
Mayra Vega, M.P.H.
Health communication
Ana E. Vélez Carrasquillo, J.D., LL.M.
Evolution of pharmacy legislation and its interface with the
practice of pharmacy; pharmacy
RESEARCH DEVELOPMENT
Research Development (EARDA)
The UPR-MSC Extramural Research Development Award Office (EARDA) funded by NICHD
facilitates research development and training for the faculty and students of
the UPR-Medical Sciences Campus. It disseminates selected information on funding
opportunities periodically and includes links for Grant Writing and other
information. Please visit us at
http://earda.rcm.upr.edu
for more information.
CENTER FOR PHARMACEUTICAL PROCESSING RESEARCH (CPPR)
The Center of Pharmaceutical Processing Research, founded in 1995, is one of over 50 Centers established by the National Science Foundation (NSF) and the only one devoted to pharmaceutical processing research. The Center comprises three Universities (Purdue, the University of Connecticut, and the University of Puerto Rico).
Mission Statement
The mission of the Center for Pharmaceutical Professing Research is to foster interdisciplinary approach to pharmaceutical professing-related research, to catalyze interaction between industrial and academic scientists, and to make the application of a basic science approach to formulation and manufacture of drug products an integral part of graduate pharmaceutical education.
Research Objectives of the Center
The broad objectives of the Center for Pharmaceutical Processing Research are to explore and develop new technology for pharmaceutical processing, to foster collaborative research projects between industrial and academic scientists, and to promote an interdisciplinary approach to training students in pharmaceutical process research and development.
Center for Pharmaceutical Processing Research Directors
Dr. Rodolfo Pinal, Director
Department of Industrial and Physical Pharmacy
575 Stadium Mall Drive, Room G22A
Purdue University
West Lafayette, IN 47907-2091
PH: 765-496-6247 Ext. 112
FAX: 765-494-6545
E-mail:
pinal@pharmacy.purdue.edu
Dr. Gregory Knipp, Associate Professor
Assistant Professor
Department of Industrial and Physical Pharmacy
IPPH Annex, Rm. 112, 1205 Kent Ave
Purdue University
West Lafayette, IN 47907-2091
PH: 765-463-1989 Ext. 112
FAX: 765-497-7290
E-mail:
gknipp@pnhs.purdue.edu
Dr. Michael J. Pikal, Site Director
School of Pharmacy
The University of Connecticut
Box U-92/372, Fairfield Road
University of Connecticut
Storrs, CT 06269-2092
PH: 860-486-2129
FAX: 860-486-4998
E-mail:
pikal@uconnvm.uconn.edu
Dr. Evone S. Ghaly, Site Director
Dept. of Pharmaceutical Sciences
Office 421, 4th floor
School of Pharmacy – Medical Sciences Campus
University of Puerto Rico
PO Box 365067
San Juan, Puerto Rico 00936-5067
PH: 787-758-2525 Ext. 5417
FAX: 787-767-2796
E-mail:
eghaly@rcm.upr.edu
Dr. Raj G. Suryanarayanan, Site Director
Collage of Pharmacy
University of Minnesota
5-130 Weaver-Densford Hall
308 Harvard Street, SE
Minneapolis, MN 55455
PH: 612-624-9626
FAX: 612-624-2974
E-mail:
surya001@tc.umn.edu
Current CPPR Faculty in Puerto Rico
Dr. Samuel Hernández
University of Puerto Rico
Department of Chemistry
PO Box 9019
Mayagüez, PR 00681-9019
PH: 787-265-5458 Ext. 3450
FAX: 787-265-3849
E-mail:
sp_hernandez@hotmail.com
Dr. Carlos Velázquez
Associate Professor
Department of Chemical Engineering
University of Puerto Rico at Mayagüez
PO Box 9046
Mayagüez, PR 00681
PH: 787-832-4040 Ext. 2576
FAX: 787-834-3655
E-mail:
c_velazquez@rumac.uprm.edu
Dr. Rodolfo Romanach
University of Puerto Rico-Mayagüez
PO Box 9019
Mayagüez, PR 00681
PH: 787-832-4040, Ext. 2600
FAX: 787-265-3849
E-mail:
rromanac@uprm.edu
CPPR Projects in Puerto Rico
Evone Ghaly, University of Puerto Rico
Wu, Y.; Kildsig, D.O.; Ghaly, E.S.
Effect of Hydrodynamic Environment on
Tablets Dissolution Rate.
Pharm. Dev. Technol. 9 (1), 25-37 (2004).
Donoso, M.; Kildsig, D.O.; Ghaly, E.S.
Prediction of Tablet Hardness and Porosity
Using Near-Infrared Diffuse Reflectance
Spectroscopy as a Nondestructive Method.
Pharm. Dev. Technol. 8 (4), 357-366 (2003).
Sepulveda, E.; Kildsig, D.O.; Ghaly, E.S.
Relationship Between Internal Phase Volume and
Emulsion Stability: The Cetyl Alcohol/Stearyl Alcohol System,
Pharm. Dev. Technol. 8 (3), 263-275 (2003).
Donoso, M.; Ghaly, E.S.
Prediction of Drug Dissolution from Tablets
Using Near-Infrared Diffuse Reflectance
Spectroscopy as a Nondestructive Method
Pharm. Dev. Technol. 9, 247-263 (2004).
Wu, Y.; Ghaly, E.S.
Effect of Hydrodynamic Environment
on Tablet Dissolution Using Flow-Through
Dissolution Apparatus. Puerto Rico Health Sci.J.
25(1), 75-81 (2006)
Donoso, M.; Ghaly, E.S.
Prediction of Tablet Disintegration Using Near
Infrared Diffuse Reflectance Spectroscopy as a
None Destructive Method
Pharm. Dev. Technol. 10, 85-191 (2005).
Donoso, M.; Ghaly, E.S.
Use of Near Infrared for Measurement of Viscosity
and Concentration of Active Ingredient in Pharmaceutical
Gel System. Pharm. Dev. Technol. 11(3), 389-397 (2006).
Rodolfo Romanach, University of Puerto Rico
J. Col., C. Peroza Meza, W. Caraballo, C. Conde,
T. Li, K. R. Morris, and R. J. Romanach
“On Line Non-Destructive Determination of Drug
Content in Moving Tablets Using Near Infrared
Spectroscopy”, Journal of Process Analytical
Technology, 2005, 2(5), 8-15.
R.J. Romanach and M.A. Santos, “Content Uniformity
Testing with Near Infrared Spectroscopy” American
Pharmaceutical Review, 2003, 6(2), 62-67.
C. Peroza Meza, M.A. Santos, and R.J. Romanach
“Quantitation of Drug Content in a Low Dosage
Formulation by Transmission Near Infrared
Spectroscopy”, 2006, 7(1), Article 29
(http://www.aapspharmscitech.org).
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